General Information
CompuSyn for Drug Combinations
and for General Dose-Effect Analysis
by Ting-Chao Chou
Memorial Sloan-Keltering Cancer Center
New York, NY
and
Nick Martin
Massachustts Institute of Technology
Cambridge, MA
Published for PC windows in 2005 by: ComboSyn, Inc., Paramus, NJ. 07652 USA
A Computer Program for PC Windows (Not for Mac)
For Single Drug and Drug Combinations Pharmacodynamics with Automated Simulations
For Dose-Effect Data Analysis from Enzymes, Receptors, Microorganisms, Cells, Animals and Clinical Trials
Also for Determination of:
IC50 IC95 ED50 LD10 LD50 ICx EDx LDx
CompuSyn General Features
New, Easy, Versatile, Automation, and Quantitation of Synergism and Antagonism; Mass-Action Law Based.
- Automated Construction of Dose-Effect Curve
- Automated Construction of Isobologram
- Automated Determination of Combination Index (CI) and Dose-Reduction Index (DRI)
- Automated Generation of Fa-CI Plot and DRI Plot
- Automated Determination of IC50, IC90, ED50, ED90, LD50, etc.
- Data Storage and Retrieval
- Color Graphics, Flexible Scale
- Editing and Transport of Data for strage and Retrieveal for Report
- User’s Guide for background, theoretical basis, illustration and sample analysis
- Small Size Experimentation, Requires Few Data Points for Single Drug or Combinations
- Can be Used for Constant or Non-Constant Ratio Drug Combination Design
- Schedule Dependency of Drug Combination
- Drug Combination Graphics at constant ratio (preferred) or at non-constant ratios
Easy, Versatile, Automative, and Quantitative
- Generate Figures, Tables, Plots and Summary in about one second after data entries
- Dose-Effect Curve and its linearization with the Median-Effect Plot
- Combination Index (CI) table and plot
- Dose-Reduction Index (DRI) table and plot
- Isobologram at any selected effect level (default at ED50, ED75 and ED90)
- Polygonogram for more than two drug combinations for semiquantitative visual inspection or projection of outcomes