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KEY REFERENCES FOR DOSE-EFFECT ANALYSIS FROM CHOU ET AL

Computer Software

  • Chou, J and Chou, T.-C. Dose-effect analysis with microcomputers: Quantitation of ED50, LD50, synergism, antagonism, low-dose risk, receptor-ligand binding and enzyme kinetics. Manual and Software, Biosoft, Cambridge, U.K., 1987. In floppy disk.(cited 181 times) No longer in use due to changes in computer hardware/software.
  • Chou, T.-C. and Hayball, M. CalcuSyn for Windows, Multiple-drug dose-effect analyzer and manual. Biosoft, Cambridge Place, Cambrige, UK. 1996. (www.biosoft.com). Based on the cited article of Chou, T-C and Talalay, P Analysis of combined drug effects: A new look at a very old problem. Trends in Pharmacol Sci 4:450-454, 1983 (Cited 336 times)
  • Chou, T.-C. and Martin, N. CompuSyn for Drug Combinations and for General Dose-Effect Analysis. PC Software for quantization of synergism and antagonism and determination of IC50, ED50 and LD50. ComboSyn, Inc. Paramus, NJ, 2005. (www.combosyn.com) [Compusyn list price was $399 since 2005. Beginning 08/01/2012, as a donation to the bio-medical communities it was offered for free download upon registration. As of 12/31/2015, there has been 12,799 downloads from 92 countries or territories.]