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KEY REFERENCES FOR DOSE-EFFECT ANALYSIS FROM CHOU ET AL

For Single Drug Analysis (IC50, ED50, LD50, ICx and Parameters m and Dm and r Values)

  • Chou, T.-C. Relationships between inhibition constants and fractional inhibitions in enzyme-catalyzed reactions with different numbers of reactants, different reaction mechanisms, and different types of mechanisms of inhibition. Mol. Pharmacol. 10: 235-247, 1974. (Cited 174 times).
  • Chou, T.-C. Derivation and properties of Michaelis-Menten type and Hill type equations for reference ligands. J. Theoret. Biol. 39: 253-276, 1976.(Cited 266 times).
  • Chou, T.-C. On the determination of availability of ligand binding sites in steady-state systems. J. Theoret. Biol. 65: 345-356, 1977.
  • Chou, T.-C. Comparison of dose-effect relationships of carcinogens following low-dose chronic exposure and high- dose single injection; An analysis by the median-effect principle. Carcinogenesis 1: 203-213, 1980. (For low dose-risk assessments of carcinogens, toxic substances, and radiation).(Cited 187 times)