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Categorized Application References

Recent References for MAL-BD/PD/CI/BI Applications: Translational Informatics from Biochemical, Cellular, Environmental, to AI Sciences (mainly 2020 – 2023)

I. Molecular, Cellular Biology and Genetics

  1. Firouzi Niaki E, Van Acker T, Imre L, Nánási Jr P, Tarapcsák S, Bacsó Z, Vanhaecke F, Szabó G. Interactions of cisplatin and daunorubicin at the chromatin level. Scientific Reports. 2020;10(1107).  https://doi.org/10.1038/s41598-020-57702-7
  2. Caillot M, Zylbersztejn F, Maitre E, Bourgeais J, Hérault O, Sola B. ROS overproduction sensitises myeloma cells to bortezomib-induced apoptosis and alleviates tumour microenvironment-mediated cell resistance. Cells. 2020;9(11). [doi: 10.3390/cells9112357]
  3. Frei T, Cella F, Tedeschi F, Gutiérrez J, Stan GB, Khammash M, Siciliano V. Characterization and mitigation of gene expression burden in mammalian cells. Nature Communications. 2020;11(1):4641.  https://doi.org/10.1038/s41467-020-18392-x
  4. Smit DJ, Cayrefourcq L, Haider M-T, Hinz N, Pantel K, Alix-Panabières C, Jücker M. High sensitivity of circulating tumor cells derived from a colorectal cancer patient for dual inhibition with AKT and mTOR inhibitors. Cells. 2020; 9(9):2129.  https://doi.org/10.3390/cells9092129
  5. de Carvalho Lima NS. Molecular characterisation and functional assessment of FGFR3 mutations in cancer. Ph.D. thesis, University of London – The Institute of Cancer Research. 2020.
  6. Ghosh C, Kumar S, Kushchayeva Y, Gaskins K, Boufraqech M, Wei D, et al. A combinatorial strategy for targeting BRAF (V600E)-mutant cancers with BRAF(V600E) inhibitor (PLX4720) and tyrosine kinase inhibitor (ponatinib). Clin Cancer Res. 2020;26(8):2022-2036. [doi: 10.1158/1078-0432.Ccr-19-1606]
  7. Obaidi I, Cassidy H, Gaspar VI, McCaul J, Higgins M, Halász M, Reynolds AL, Kennedy BN, McMorrow T. Curcumin sensitizes kidney cancer cells to TRAIL-induced apoptosis via ROS mediated activation of JNK-CHOP pathway and upregulation of DR4. Biology. 2020;9(5):92.  https://doi.org/10.3390/biology9050092
  8. Wakabayashi R, Hattori Y, Hosogi S, Toda Y, Takata K, Ashihara E. A novel dipeptide type inhibitor of the Wnt/β-catenin pathway suppresses proliferation of acute myelogenous leukemia cells. Biochem Biophys Res Commun. 2021;535:73-79. [doi: 10.1016/j.bbrc.2020.12.027]
  9. Khairy A, Hammoda HM, Celik I, Zaatout HH, Ibrahim RS. Discovery of potential natural dihydroorotate dehydrogenase inhibitors and their synergism with brequinar via integrated molecular docking, dynamic simulations and in vitro approach. Scientific Reports. 2022;12(19037).  https://doi.org/10.1038/s41598-022-23006-1
  10. Sun J, Zhang Q, Sun X, Xue A, Gao X, Shen K. THZ1 targeting CDK7 suppresses c-KIT transcriptional activity in gastrointestinal stromal tumours. Cell Commun Signal. 2022; 20(138).  https://doi.org/10.1186/s12964-022-00928-x
  11. Yao H, Song W, Cao R, Ye C, Zhang L, Chen H, Wang J, Shi Y, Li R, Li Y, Liu X, Zhou X, Shao R, Li L. An EGFR/HER2-targeted conjugate sensitizes gemcitabine-sensitive and resistant pancreatic cancer through different SMAD4-mediated mechanisms. Nature Communication. 2022;13(5506).  https://doi.org/10.1038/s41467-022-33037-x
  12. Rukhlenko OS, Halasz M, Rauch N, Zhernovkov V, Kolch W, Kholodenko BN, et al. Control of cell state transitions. Nature. 14 September 2022.  https://doi.org/10.1038/s41586-022-05194-y
  13. Huangfu L, Wang X, Tian S, Chen J, Wang X, Fan B, Yao Q, Wang G, Chen C, Han J, Xing X, Ji J. Piceatannol enhances Beclin-1 activity to suppress tumor progression and its combination therapy strategy with everolimus in gastric cancer. Science China Life Sciences. 20 October 2022.  https://doi.org/10.1007/s11427-022-2185-9
  14. Kong S, Moharil P, Handly-Santana A, Boehnke N, Panayiotou R, Gomerdinger V, Covarrubias G, Pires IS, Zervantonakis I, Brugge J, Hammond PT. Synergistic combination therapy delivered via layer-by-layer nanoparticles induces solid tumor regression of ovarian cancer. Bioengineering & Translational Medicine. November 8, 2022.  https://doi.org/10.1002/btm2.10429
  15. Golub V, Ramakrishnan S, Reddy DS. Isobolographic analysis of adjunct Antiseizure activity of the FDA-approved cannabidiol with neurosteroids and benzodiazepines in adult refractory focal onset epilepsy. Experimental Neurology. 2023;360(114294).  https://doi.org/10.1016/j.expneurol.2022.114294
  16. Tran VL, Liu P, Katsumura KR, Kim E, Schoff BM, Johnson KD, Bresnick EH. Restricting genomic actions of innate immune mediators on fetal hematopoietic progenitor cells. iScience. 2023;106297.  https://doi.org/10.1016/j.isci.2023.106297
  17. Malik N, Kim YI, Yan H, Tseng YC, du Bois W, Ayaz G, Tran AD, Vera Ramírez L, Yang HH, Michalowski AM, Kruhlak M, Lee M, Hunter KW, Huang J. Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer. Cancer Research. February 14, 2023.  https://doi.org/10.1158/0008-5472.CAN-22-2525
  18. Parinandi NL, Liaugminas A, Oliver PJ, Varadharaj S, Yenigalla A, Elliott AC, Arutla S, Campbell SJ, Kotha SR, Sherwani SI, Kutala VK, McDaniel JC, Maddipati KR, Kuppusamy P, Hund TJ. Classic phytochemical antioxidant and lipoxygenase inhibitor, nordihydroguaiaretic acid, activates phospholipase d through oxidant signaling and tyrosine phosphorylation leading to cytotoxicity in lung vascular endothelial cells. Cell Biochemistry and Biophysics. February 23, 2023.  https://doi.org/10.1007/s12013-023-01128-1
  19. Wen T, Geng M, Bai E, Wang X, Miao H, Chen Z, Zhou H, Wang J, Shi J, Zhang Y, Lei M, Zhu Y. KPT-330 and Y219 exert a synergistic anti-tumor effect in triple-negative breast cancer through inhibiting NF-κB signaling. FEBS Open Bio. February 27, 2023.  https://doi.org/10.1002/2211-5463.13588
  20. Xie J, Liu J, Zhao M, Li X, Wang Y, Zhao Y, Cao H, Ji M, Chen M, Hou P. Disulfiram/Cu kills and sensitizes BRAF-mutant thyroid cancer cells to BRAF kinase inhibitor by ROS-dependently relieving feedback activation of MAPK/ERK and PI3K/AKT pathways. International Journal of Molecular Sciences. 2023;24(4):3418.  https://doi.org/10.3390/ijms24043418
  21. Zecha J, Bayer FP, Wiechmann S, Woortman J, Berner N, Müller J, Schneider A, Kramer K, Abril-Gil M, Hopf T, Reichart L, Chen L, Hansen FM, Lechner S, Samaras P, Eckert S, Lautenbacher L, Reinecke M, Hamood F, Prokofeva P, Vornholz L, Falcomatà C, Dorsch M, Schröder A, Venhuizen A, Wilhelm S, Médard G, Stoehr G, Ruland J, Grüner BM, Saur D, Buchner M, Ruprecht B, Hahne H, The M, Wilhelm M, Kuster B. Decrypting drug actions and protein modifications by dose-and time-resolved proteomics. Science. 2023;eade3925.  https://doi.org/10.1126/science.ade3925
  22. He X, Riceberg J, Soucy T, Koenig E, Minissale J, Gallery M, Bernard H, Yang X, Liao H, Rabino C, Shah P, Xega K, Yan ZH, Sintchak M, Bradley J, Xu H, Duffey M, England D, Mizutani H, Hu Z, Guo J, Chau R, Dick LR, Brownell JE, Newcomb J, Langston S, Lightcap ES, Bence N, Pulukuri SM. Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor. Nature Chemical Biology. 2017;13(11):1164-1171.  https://doi.org/10.1038/nchembio.2463
  23. Wang D, Yin Z, Wang H, Wang L, Li T, Xiao R, Xie T, Han R, Dong R, Liu H, Liang K, Qing G. The super elongation complex drives transcriptional addiction in MYCN-amplified neuroblastoma. Science Advances. 2023;9(13):eadf0005.  https://doi.org/10.1126/sciadv.adf0005
  24. Kong W, Zhu L, Li T, Chen J, Fan B, Ji W, Zhang C, Cai X, Hu C, Sun X, Cao P. Azeliragon inhibits PAK1 and enhances the therapeutic efficacy of AKT inhibitors in pancreatic cancer. European Journal of Pharmacology. 2023;175703.  https://doi.org/10.1016/j.ejphar.2023.175703
  25. Kotze AC, Rolls NM. Reduced synergistic efficacy of piperonyl butoxide in combination with alpha-cypermethrin in vitro in an insecticide-resistant strain of the sheep blowfly, Lucilia cuprina. Veterinary Parasitology. 2023;317:109917.  https://doi.org/10.1016/j.vetpar.2023.109917
  26. Liu P, Zhao M, Lin Y, Jiang X, Xia T, Li Y, Lu Y, Jiang L. Platycodin D induces proliferation inhibition and mitochondrial apoptosis in diffuse large B-cell lymphoma. Experimental Hematology. 2023;S0301-472X(23)00160-1.  https://doi.org/10.1016/j.exphem.2023.04.002
  27. Zhou X, Afzal S, Zheng YF, Münch G, Li CG. Synergistic protective effect of curcumin and resveratrol against oxidative stress in endothelial EAhy926 cells. Evid Based Complement Alternat Med. 2021;2021:2661025.  https://doi.org/10.1155/2021/2661025
  28. Hiroki H, Ishii Y, Piao J, Namikawa Y, Masutani M, Honda H, Akahane K, Inukai T, Morio T, Takagi M. Targeting Poly(ADP)ribose polymerase in BCR/ABL1-positive cells. Scientific Reports. 2023;13(1):7588.  https://doi.org/10.1038/s41598-023-33852-2
  29. Elkateb AS, Nofal S, Ali SA, Atya HB. Camptothecin sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via suppression of Nrf2. Inflammation. May 12, 2023.  https://doi.org/10.1007/s10753-023-01823-4
  30. Dutta S, Sengupta P, Bagchi S, Chhikara BS, Pavlík A, Sláma P, Roychoudhury S. Reproductive toxicity of combined effects of endocrine disruptors on human reproduction. Frontiers in Cell and Developmental Biology. 2023;11:1162015.  https://doi.org/10.3389/fcell.2023.1162015
  31. Soltannezhad S, Jouni FJ, Osgoei LT. The combined therapeutic effect of capecitabine and naringin on HER2+ (SK-BR-3) and HER2- (MCF-7) human breast cancer cells lines. Scientific Reports. May 9, 2023 (Preprint).  https://doi.org/10.21203/rs.3.rs-2887641/v1
  32. Hong X, Hsieh MT, Tseng TY, Lin HY, Chang HC, Yau ST, Cheng WC, Ke B, Liao HH, Wu CY, Liu AA, Wu MM, Huang KY, Yang PC, Kuo SC, Hung MC, Lee PC. Diarylheptanoid 35d overcomes EGFR TKI resistance by inducing hsp70-mediated lysosomal degradation of EGFR in EGFR-mutant lung adenocarcinoma. Journal of Biological Chemistry. 2023;104814.  https://doi.org/10.1016/j.jbc.2023.104814

II. Anti-Cancer, Anti-Viral, and Anti-Microbial Agents Applications

  1. Luszczak S, Simpson BS, Stopka-Farooqui U, Sathyadevan VK, Echeverria LMC, Kumar C, Costa H, Haider A, Freeman A, Jameson C, Ratynska M, Ben-Salha I, Sridhar A, Shaw G, Kelly JD, Pye H, Gately KA, Whitaker HC, Heavey S. Co-targeting PIM and PI3K/mTOR using multikinase inhibitor AUM302 and a combination of AZD-1208 and BEZ235 in prostate cancer. Scientific Reports. 2020;10(1):14380.  https://doi.org/10.1038/s41598-020-71263-9
  2. Bauer A, Ziani W, Lindemuth E, Kuri-Cervantes L, Li H, Lee FH, Watkins M, Xu H, Veazey R, Bar K. Novel transmitted/founder SHIVs for HIV latency and cure research. Journal of Virology. 2020;94.  https://doi.org/10.1128/JVI.01659-19
  3. El Guerrab, A, Bamdad, M, Bignon, YJ, Penault-Llorca F, Aubel C. Co-targeting EGFR and mTOR with gefitinib and everolimus in triple-negative breast cancer cells. Scientific Reports. 2020;10(6367).  https://doi.org/10.1038/s41598-020-63310-2
  4. Turner TH, Alzubi MA, Harrell JC. Identification of synergistic drug combinations using breast cancer patient-derived xenografts. Scientific Reports. 2020;10(1):1493.  https://doi.org/10.1038/s41598-020-58438-0
  5. Endersby R, Whitehouse J, Pribnow A, Kuchibhotla M, Hii H, Carline B, Gande S, Stripay J, Ancliffe M, Howlett M, Schoep T, George C, Andradas C, Dyer P, Schluck M, Patterson B, Tacheva-Gigorova SK, Cooper MN, Robinson G, Stewart C, Pfister SM, Kool M, Milde T, Gajjar A, Johns T, Wechsler-Reya RJ, Roussel MF, Gottardo NG. Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma. Science Translational Medicine. 2021;13(577).  https://doi.org/10.1126/scitranslmed.aba7401
  6. White KM, Rosales R, Yildiz S, Kehrer T, Miorin L, Moreno E, Jangra S, Uccellini MB, Rathnasinghe R, Coughlan L, Martinez-Romero C, Batra J, Rojc A, Bouhaddou M, Fabius JM, Obernier K, Dejosez M, Guillén MJ, Losada A, Avilés P, Schotsaert M, Zwaka T, Vignuzzi M, Shokat KM, Krogan NJ, García-Sastre A. Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A. Science. 2021;371(6532):926-931.  https://doi.org/10.1126/science.abf4058
  7. Hinz N, Baranowsky A, Horn M, Kriegs M, Sibbertsen F, Smit DJ, Clezardin P, Lange T, Schinke T, Jücker M. Knockdown of AKT3 activates HER2 and DDR kinases in bone-seeking breast cancer cells, promotes metastasis in vivo and attenuates the TGFβ/CTGF axis. Cells. 2021;10(430).  https://doi.org/10.3390/cells10020430
  8. Lin SF, Yeh CN, Huang YT, Chou TC, Wong RJ. Therapeutic inhibition of polo-like kinases in anaplastic thyroid cancer. Cancer Sci. 2021;112(2):803-814.  https://doi.org/10.1111/cas.14769
  9. Chu YY, Chen MK, Wei Y, Lee HH, Xia W, Hung MC. Targeting the ALK–CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex. Nat Cancer. 2022;3:1211–1227.  https://doi.org/10.1038/s43018-022-00438-2
  10. Ding X, Sharko AC, McDermott MSJ, Schools GP, Chumanevich A, Ji H, Li J, Zhang L, Mack ZT, Sikirzhytski V, Shtutman M, Ivers L, O’Donovan N, Crown J, Győrffy B, Chen M, Roninson IB, Broude EV. Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in vitro and in vivo. Proceedings of the National Academy of Sciences of the USA. 2022;119(32).  https://doi.org/10.1073/pnas.2201073119
  11. Chen Y, Wang X, Shi H, Zou P. Montelukast inhibits HCoV-OC43 infection as a viral inactivator. Viruses. 2022;14(5):861.  https://doi.org/10.3390/v14050861
  12. Chang MR, Tomasovic L, Kuzmina NA, Ronk AJ, Byrne PO, Marasco WA. IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern. Nature Communications. 2022;13(5814).  https://doi.org/10.1038/s41467-022-33030-4
  13. Okuno K, Xu C, Pascual-Sabater S, Tokunaga M, Han H, Fillat C, Kinugasa Y, Goel A. Berberine Overcomes Gemcitabine-Associated Chemoresistance through Regulation of Rap1/PI3K-Akt Signaling in Pancreatic Ductal Adenocarcinoma. Pharmaceuticals. 2022;15(10):1199.  https://doi.org/10.3390/ph15101199
  14. Guo Y, Zhu Z, Huang Z, Cui L, Yu W, Hong W, Zhou Z, Du P, Liu CY. CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis. Nat Commun. 2022;13(1):4995.  https://doi.org/10.1038/s41467-022-32674-6
  15. Dar AA, Bezrookove V, Nosrati M, Ice R, Patino JM, Vaquero EM, Parrett B, Leong SP, Kim KB, Debs RJ, Soroceanu L, Miller JR 3rd, Desprez PY, Cleaver JE, Salomonis N, McAllister S, Kashani-Sabet M. Bromodomain inhibition overcomes treatment resistance in distinct molecular subtypes of melanoma. Proc Natl Acad Sci USA. 2022; 119(34):e2206824119.  https://doi.org/10.1073/pnas.2206824119
  16. Ding X, Sharko AC, McDermott MSJ, Schools GP, Chumanevich A, Ji H, Li J, Zhang L, Mack ZT, Sikirzhytski V, Shtutman M, Ivers L, O’Donovan N, Crown J, Győrffy B, Chen M, Roninson IB, Broude EV. Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in vitro and in vivo. Proc Natl Acad Sci USA. 2022;119(32).  https://doi.org/10.1073/pnas.2201073119
  17. Koch J, Schober SJ, Hindupur SV, Holm PS. Targeting the Retinoblastoma/E2F repressive complex by CDK4/6 inhibitors amplifies oncolytic potency of an oncolytic adenovirus. Nat Commun. 10 August 2022.;13:4689.  https://doi.org/10.1038/s41467-022-32087-5
  18. Huang Y-F, Yang H-W, Lin-Shiau S-Y. Synergistic antibacterial effects of 5-fluorouracil or thioridazine in combination with phytopolyphenols on cultured Porphyromonas gingivalis. Journal of Dental Sciences. November 5, 2022.  https://doi.org/10.1016/j.jds.2022.10.026
  19. Chintala NK, Choe JK, McGee E, Bellis R, Saini JK, Banerjee S, Moreira AL, Zauderer MG, Adusumilli PS, Rusch VW. Correlative analysis from a phase I clinical trial of intrapleural administration of oncolytic vaccinia virus (Olvi-vec) in patients with malignant pleural mesothelioma. Frontiers in Immunology. 2023;14:1112960.  https://doi.org/10.3389%2Ffimmu.2023.1112960
  20. Xu D, Yu J, Yang Y, Du Y, Lu H, Zhang S, Feng Q, Yu Y, Hao L, Shao J, Chen L. RBX1 regulates PKM alternative splicing to facilitate anaplastic thyroid carcinoma metastasis and aerobic glycolysis by destroying the SMAR1/HDAC6 complex. Cell & Bioscience. 2023;13(1):36.  https://doi.org/10.1186/s13578-023-00987-8
  21. Tsukamoto Y, Hiono T, Yamada S, Matsuno K, Faist A, Claff T, Hou J, Namasivayam V, Vom Hemdt A, Sugimoto S, Ng JY, Christensen MH, Tesfamariam YM, Wolter S, Juranek S, Zillinger T, Bauer S, Hirokawa T, Schmidt FI, Kochs G, Shimojima M, Huang YS, Pichlmair A, Kümmerer BM, Sakoda Y, Schlee M, Brunotte L, Müller CE, Igarashi M, Kato H. Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication. Science. 2023;379(6632):586-591.
  22. Yao R, Yang F, Liu J, Jiano Q, Yu H, Nie X, Li H, Wang X, Xue F. Therapeutic drug combinations against COVID-19 obtained by employing a collaborative filtering method. Heliyon. 2023;9(3).  https://doi.org/10.1016/j.heliyon.2023.e14023
  23. Hu Y, Zhu Y, Yu Y, Liu N, Ju X, Ding Q, He Y. Design and characterization of novel SARS-CoV-2 fusion inhibitors with N-terminally extended HR2 peptides. Antiviral Research. 2023;212:105571.  https://doi.org/10.1016/j.antiviral.2023.105571
  24. Pan ST, Ye FF, Huang G, Qiu JX. Plumbagin enhances the anticancer effects of PF chemotherapy via downregulation of the PI3K/AKT/mTOR/p70S6K pathway in human tongue squamous cell carcinoma. Journal of Oncology. February 13, 2023.  https://doi.org/10.1155/2023/8306514
  25. Aragona C, Bezerra Espinola MS, Bilotta G, Porcaro G, Calcagno M. Evaluating the efficacy of Pervistop®, a new combination based on EGCG, folic acid, vitamin B12 and hyaluronic acid on patients with human papilloma virus (HPV) persistent infections and cervical lesions: A pilot study. Journal of Clinical Medicine. 2023;12(6):2171.  https://doi.org/10.3390/jcm12062171
  26. de León P, Cañas-Arranz R, Bustos MJ, Sáiz M, Sobrino F. Inhibition of Human Coronaviruses by Combinations of Host-Targeted and Direct-Acting Antivirals. Antimicrobial Agents and Chemotherapy. 2023;e0170322.  https://doi.org/10.1128/aac.01703-22
  27. Opydo M, Mlyczyńska A, Mlyczyńska E, Rak A, Kolaczkowska E. Synergistic Action of MCL-1 Inhibitor with BCL-2/BCL-XL or MAPK Pathway Inhibitors Enhances Acute Myeloid Leukemia Cell Apoptosis and Differentiation. International Journal of Molecular Sciences. 2023;24(8):7180.  https://doi.org/10.3390/ijms24087180
  28. Ketchemen JP, Babeker H, Tikum AF, Nambisan AK, Njotu FN, Nwangele E, Fonge H. Biparatopic anti-HER2 drug radioconjugates as breast cancer theranostics. British Journal of Cancer. April 24, 2023.  https://doi.org/10.1038/s41416-023-02272-4
  29. Buckley PT, Chan R, Fernandez J, Luo J, Lacey KA, DuMont AL, O'Malley A, Brezski RJ, Zheng S, Malia T, Whitaker B, Zwolak A, Payne A, Clark D, Sigg M, Lacy ER, Kornilova A, Kwok D, McCarthy S, Wu B, Morrow B, Nemeth-Seay J, Petley T, Wu S, Strohl WR, Lynch AS, Torres VJ. Multivalent human antibody-centyrin fusion protein to prevent and treat Staphylococcus aureus infections. Cell Host & Microbe. 2023;S1931-3128(23)00148-8.  https://doi.org/10.1016/j.chom.2023.04.004
  30. Muraro E, Vinante L, Fratta E, Bearz A, Höfler D, Steffan A, Baboci L. Metronomic chemotherapy: Anti-tumor pathways and combination with immune checkpoint inhibitors. Cancers. 2023;15(9):2471.  https://doi.org/10.3390/cancers15092471
  31. Wang X, Mak PY, Mu H, Tao W, Rao A, Visweswaran R, Ruvolo V, Pachter JA, Weaver DT, Andreeff M, Xu B, Carter BZ. Combinatorial inhibition of focal adhesion kinase and BCL-2 enhances antileukemia activity of venetoclax in acute myeloid leukemia. Molecular Cancer Therapeutics. 2020;19(8):1636-1648.  https://doi.org/10.1158/1535-7163.MCT-19-0841
  32. Alves AB, da Silva Bortoleti BT, Tomiotto-Pellissier F, Ganaza AFM, Gonçalves MD, Carloto ACM, Rodrigues ACJ, Silva TF, Nakazato G, Kobayashi RKT, Lazarin-Bidóia D, Miranda-Sapla MM, Costa IN, Pavanelli WR, Conchon-Costa I. Synergistic antileishmanial effect of oregano essential oil and silver nanoparticles: Mechanisms of action on leishmania amazonensis. Pathogens. 2023;12(5):660.  https://doi.org/10.3390/pathogens12050660
  33. Schelker C, Nowak-Sliwinska P, Borchard G. HDACIs and TKIs combinations and their liposomal delivery for cancer treatment. Journal of Controlled Release. 2023;358:59-77.  https://doi.org/10.1016/j.jconrel.2023.04.006
  34. Wei SJ, Yang IH, Mohiuddin IS, Kshirsagar GJ, Nguyen TH, Trasti S, Maurer BJ, Kang MH. DNA-PKcs as an upstream mediator of OCT4-induced MYC activation in small cell lung cancer. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2023;194939.  https://doi.org/10.1016/j.bbagrm.2023.194939
  35. Peng WT, Jin X, Xu XE, Yang YS, Ma D, Shao ZM, Jiang YZ. Inhibition of ACAA1 Restrains Proliferation and Potentiates the Response to CDK4/6 Inhibitors in Triple-Negative Breast Cancer. Cancer Research. 2023;83(10):1711-1724.  https://doi.org/10.1158/0008-5472.CAN-22-2143
  36. Chu W, Houston ZH, Fletcher NL, Huda P, Ahamed M, Lim TX, Day BW, Pinkham M, Thurecht KJ. Development and Validation of a Targeted Treatment for Brain Tumors Using a Multi-Drug Loaded, Relapse-Resistant Polymeric Theranostic. Biomacromolecules. 2023;10.1021/acs.biomac.3c00138.  https://doi.org/10.1021/acs.biomac.3c00138
  37. Valinciute G, Ecker J, Selt F, Hielscher T, Sigaud R, Ridinger J, Thatikonda V, Gatzweiler C, Robinson S, Talbot J, Bernardi F, Picard D, Blattner-Johnson M, Schmid S, Jones DT, van Tilburg CM, Capper D, Kool M, Remke M, Oehme I, Pfister SM, Roussel MF, Ayrault O, Witt O, Milde T. Class I HDAC inhibitor entinostat synergizes with PLK1 inhibitors in MYC-amplified medulloblastoma cells. Journal of Neuro-Oncology. 2023;10.1007/s11060-023-04319-1.  https://doi.org/10.1007/s11060-023-04319-1
  38. Shuvalov O, Kirdeeva Y, Fefilova E, Netsvetay S, Zorin M, Vlasova Y, Fedorova O, Daks A, Parfenyev S, Barlev N. 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells. Metabolites. 2023;13(5):656.  https://doi.org/10.3390/metabo13050656
  39. Donkor MN, Donkor AM, Mosobil R. Combination therapy: synergism among three plant extracts against selected pathogens. BMC Research Notes. 2023;16(1):83.  https://doi.org/10.1186/s13104-023-06354-7
  40. Struble EB, Rawson JMO, Stantchev T, Scott D, Shapiro MA. Uses and Challenges of Antiviral Polyclonal and Monoclonal Antibody Therapies. Pharmaceutics. 2023;15(5):1538.  https://doi.org/10.3390/pharmaceutics15051538

III. Clinical Investigation Applications

  1. Hu L, Li B, Chen G, Song D, Xu Z, Gao L, Xi M, Zhou J, Li L, Zhang H, Feng Q, Wang Y, Lu K, Lu Y, Bu W, Wang H, Wu X, Zhu W, Shi J. A novel M phase blocker, DCZ3301 enhances the sensitivity of bortezomib in resistant multiple myeloma through DNA damage and mitotic catastrophe. Journal of Experimental & Clinical Cancer Research. 2020;39(1):105.  https://doi.org/10.1186/s13046-020-01597-9
  2. Sweet K, Komrokji R, Padron E, Cubitt CL, Turner JG, Zhou J, et al. Phase I clinical trial of selinexor in combination with daunorubicin and cytarabine in oreviously untreated poor-risk acute myeloid leukemia. Clin Cancer Res. 2020;26(1):54-60. [doi: 10.1158/1078-0432.Ccr-19-2169]
  3. Sweet K, Komrokji R, Padron E, Cubitt CL, Turner JG, Zhou J, List AF, Sallman DA, Dawson JL, Sullivan DM, Chavez J, Shah BD, Lancet JE. Phase I clinical trial of selinexor in combination with daunorubicin and cytarabine in previously untreated poor-risk acute myeloid leukemia. Clinical Cancer Research. 2020;26(1):54-60.  https://doi.org/10.1158/1078-0432.ccr-19-2169
  4. Roze J, Sendino Garví E, Stelloo E, Stangl C, Sereno F, Duran K, Groeneweg J, Paijens S, Nijman H, van Meurs H, van Lonkhuijzen L, Piek J, Lok C, Jonges G, Witteveen P, Verheijen R, van Haaften G, Zweemer R, Monroe G. In vitro systematic drug testing reveals carboplatin, paclitaxel, and alpelisib as a potential novel combination treatment for adult granulosa cell tumors. Cancers. 2021;13(3):368.  https://doi.org/10.3390/cancers13030368
  5. Roas M, Vick B, Kasper M-A, Spiekermann K. Targeting FLT3 by new-generation antibody-drug-conjugate in combination with kinase inhibitors for treatment of AML. Blood. 18 August 2022.  http://dx.doi.org/10.1182/blood.2021015246
  6. Elakad O, Häupl B, Labitzky V, Yao S, Küffer S, von Hammerstein-Equord A, Danner BC, Jücker M, Urlaub H, Lange T, Ströbel P, Oellerich T, Bohnenberger H. Activation of CD44/PAK1/AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer. npj Precision Oncology. 2022;6(52).  https://doi.org/10.1038/s41698-022-00296-2
  7. Haynes BM, Cunningham K, Shekhar MPV. RAD6 inhibition enhances paclitaxel sensitivity of triple negative breast cancer cells by aggravating mitotic spindle damage. BMC Cancer. 2022;1073.  https://doi.org/10.1186/s12885-022-10119-z
  8. Chung JH, Choi HJ, Kang YJ, Kim YS, Lee SY, Kwon RJ, Jeong HS, Park SJ, Jeong Y, Kang D, Ko J, Noh SG, Chung HY, Moon HR, Yoon SH. MHY4571, a novel diarylcyclohexanone derivative, exerts anti-cancer activity by regulating the PKA-cAMP-response element-binding protein pathway in squamous cell lung cancer. Exp Haematol Oncol. 2022;11(68).  https://doi.org/10.1186/s40164-022-00324-8
  9. Liu Y, Betori RC, Pagacz J, Frost GB, Efimova EV, Wu D, Wolfgeher DJ, Bryan TM, Cohen SB, Scheidt KA, Kron SJ. Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization. Cell Chemical Biology. 2022;29(10): 1517-1531.  https://doi.org/10.1016/j.chembiol.2022.09.002
  10. Olszewska P, Pazdrak B, Kruzel ML. Human lactoferrin synergizes with etoposide to inhibit lung adenocarcinoma cell growth while attenuating etoposide-mediated cytotoxicity of human endothelial cells. Biomedicines. 2022;10(10):2429.  https://doi.org/10.3390/biomedicines10102429
  11. Zhang Z, Shen C, Zhou F. The natural medicinal fungus Huaier promotes the anti-hepatoma efficacy of sorafenib through the mammalian target of rapamycin-mediated autophagic cell death. Medical Oncology. 2022;39(221).  https://doi.org/10.1007/s12032-022-01797-7
  12. April-Monn S, Detjen K, Kirchner P, Bräutigam K, Trippel MA, Marques IJ, Grob T, Statzer C, Maire RS, Kollàr A, Chouchane A, Kunze K, Horst D, Sadowski MC, Schrader J, Mercader N, Marinoni I, Wiedenmann B, Perren A. Patient-derived tumoroids of advanced high-grade neuroendocrine neoplasms mimic patient chemotherapy responses and guide the design of personalized combination therapies. bioRxiv. December 11, 2022.  https://doi.org/10.1101/2022.12.10.519855
  13. Guo Q, Li Y, Xu S, Wang P, Qian K, Yang P, Sheng D, Wang L, Cheng Y, Meng R, Cao J, Luo H, Wei Y, Zhang Q. Brain-neuron targeted nanoparticles for peptide synergy therapy at dual-target of Alzheimer's disease. Journal of Controlled Release. 2023;355:604-621.  https://doi.org/10.1016/j.jconrel.2023.01.074
  14. Sinha VK, Snoeys J, Osselaer NV, Peer AV, Mackie C, Heald D. From preclinical to human--prediction of oral absorption and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach in an industrial setting: a workflow by using case example. Biopharmaceutics & Drug Disposition. 2012;33(2):111-121.  https://doi.org/10.1002/bdd.1782
  15. Li S, Fu J, Walker CJ, Yang J, Bhutani D, Chakraborty R, Mamillapalli N, Mapara MY, Landesman Y, Lentzsch S. Dual targeting of protein translation and nuclear protein export results in enhanced anti-myeloma effects. Blood Advances. February 24, 2023.  https://doi.org/10.1182/bloodadvances.2021006638
  16. Besse L, Kraus M, Besse A, Driessen C, Tarantino I. The cytotoxic activity of carfilzomib together with nelfinavir is superior to the bortezomib/nelfinavir combination in non-small cell lung carcinoma. Scientific Reports. 2023; 13(1):4411.  https://doi.org/10.1038/s41598-023-31400-6
  17. Lang M, Schmidt LS, Wilson KM, Ricketts CJ, Sourbier C, Vocke CD, Wei D, Crooks DR, Yang Y, Gibbs BK, Zhang X, Klumpp-Thomas C, Chen L, Guha R, Ferrer M, McKnight C, Itkin Z, Wangsa D, Wangsa D, James A, Difilippantonio S, Karim B, Morís F, Ried T, Merino MJ, Srinivasan R, Thomas CJ, Linehan WM. High-throughput and targeted drug screens identify pharmacological candidates against MiT-translocation renal cell carcinoma. Journal of Experimental & Clinical Cancer Research. 2023;42(1):99.  https://doi.org/10.1186/s13046-023-02667-4
  18. Courtois L, Cabannes-Hamy A, Kim R, Delecourt M, Pinton A, Charbonnier G, Féroul M, Smith C, Tueur G, Pivert C, Balducci E, Simonin M, Angel LH, Spicuglia S, Boissel N, Andrieu GP, Asnafi V, Rousselot P, Lhermitte L. IL7-receptor expression is frequent in T-cell acute lymphoblastic leukemia and predicts sensitivity to JAK-inhibition. Blood. 2023;blood.2022017948.  https://doi.org/10.1182/blood.2022017948
  19. Kong T, Yu L, Laranjeira ABA, Fisher DAC, He F, Cox MJ, Oh ST. Comprehensive profiling of clinical JAK inhibitors in myeloproliferative neoplasms. American journal of Hematology. 2023;10.1002/ajh.26935.  https://doi.org/10.1002/ajh.26935
  20. Cesari E, Ciucci A, Pieraccioli M, Caggiano C, Nero C, Bonvissuto D, Sillano F, Buttarelli M, Piermattei A, Loverro M, Camarda F, Greco V, De Bonis M, Minucci A, Gallo D, Urbani A, Vizzielli G, Scambia G, Sette C. Dual inhibition of CDK12 and CDK13 uncovers actionable vulnerabilities in patient-derived ovarian cancer organoids. Journal of Experimental & Clinical Cancer Research. 2023;42(1):126.  https://doi.org/10.1186/s13046-023-02682-5

IV. Agricultural, Marine, Phytotheraputic, and Food Sciences

  1. Zhang Q, Yang T, Li D, Ma M, Liang X, Ma Z, Ye Q, Yang H, Li M, Qu A, Chen Y. The synergistic effect of Angelica sinensis (Oliv.) Diels and Rehmannia glutinosa (Gaertn.) DC. on antioxidant activity and protective ability against cell injury. Journal of Food Biochemistry. May 2022;46(8).  https://doi.org/10.1111/jfbc.14196
  2. Boukraa N, Ladjel S, Benlamoudi W, Goudjil MB, Berrekbia M, Eddoud A. Insecticidal and repellent activities of Artemisia herba alba Asso, Juniperus phoenicea L and Rosmarinus officinalis L essential oils in synergized combinations against adults of Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae). Biocatalysis and Agricultural Biotechnology. 2022;45.  https://doi.org/10.1016/j.bcab.2022.102513
  3. Hendrival H, Safriyanur A, Hafifiah H, Munauwar MM, Baidhawi B. Toxicity single and mixture of leaf powder papaya and crown flower on golden apple snail. Jurnal Agrotek Tropika. 2022.;10(3):403-411.  http://dx.doi.org/10.23960/jat.v10i3.5537
  4. Dyshlovoy SA, Shubina LK, Makarieva TN, et al. New diterpenes from the marine sponge Spongionella sp. overcome drug resistance in prostate cancer by inhibition of P-glycoprotein. Sci Rep. 2022;12:13570.  https://doi.org/10.1038/s41598-022-17447-x
  5. Gao F, Li Y, Zhao H, Liang Y, Liu Z. Sub-chronic, low dose co-exposure to Aflatoxin B1 and Microcystin-LR in C57BL/6 mice significantly alters the cytokine response in serum and liver. CyTA - Journal of Food. 2022;20(1):271-284.  https://doi.org/10.1080/19476337.2022.2130436
  6. Doello K, Mesas C, Quiñonero F, Rama AR, Vélez C, Perazzoli G, Ortiz R. Antitumor effect of traditional drugs for neurological disorders: preliminary studies in neural tumor cell lines. Neurotoxicity Research. November 30, 2022.  https://doi.org/10.1007/s12640-022-00606-3
  7. Seoane M, Conde-Pérez K, Esperanza M, Cid A, Rioboo C. Unravelling joint cytotoxicity of ibuprofen and oxytetracycline on Chlamydomonas reinhardtii using a programmed cell death-related biomarkers panel. Aquatic Toxicology. 2023;257.  https://doi.org/10.1016/j.aquatox.2023.106455
  8. Punginelli D, Catania V, Abruscato G, Luparello C, Vazzana M, Mauro M, Cunsolo V, Saletti R, Di Francesco A, Arizza V, Schillaci D. New bioactive peptides from the Mediterranean Seagrass Posidonia oceanica (L.) Delile and their impact on antimicrobial activity and apoptosis of human cancer cells. International Journal of Molecular Sciences. 2023;24(6):5650.  https://doi.org/10.3390/ijms24065650
  9. Lu M, Xing H, Shao W, Wu P, Fan Y, He H, Barth S, Zheng A, Liang X, Huang Y. Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles. Acta Pharmaceutica Sinica B. March 29, 2023.  https://doi.org/10.1016/j.apsb.2023.03.020
  10. Kamel AA, Marzouk WM, Hashish ME, Abd El-Daym MR. Synergistic antioxidant activity of honey bee products and their mixtures. Plant Archives. 2023;23(1):81-89.  https://doi.org/10.51470/PLANTARCHIVES.2023.v23.no1.014
  11. Li S, Wu H, Chen M, Tollefsbol TO. Paternal combined botanicals contribute to the prevention of estrogen receptor-negative mammary cancer in transgenic mice. The Journal of Nutrition. 2023;S0022-3166(23)37593-X.  https://doi.org/10.1016/j.tjnut.2023.05.001
  12. Ye Y, Wei K, Ji J, Ning X, Wang JS, Sun X. Toxicity and metabolic effect of combined deoxynivalenol, 3-acetyldeoxynivalenol, and 15-acetyldeoxynivalenol on a Caco-2 cell model. Food Bioscience. 2023;53:102718.  https://doi.org/10.1016/j.fbio.2023.102718
  13. Zhou X, Afzal S, Zheng YF, Münch G, Li CG. Synergistic protective effect of curcumin and resveratrol against oxidative stress in endothelial EAhy926 cells. Evid Based Complement Alternat Med. 2021;2021:2661025.  https://doi.org/10.1155/2021/2661025
  14. Daker M, Jayaweera U, Marzuki M, Gunasegaran G, Chew YL, Ahmad M, Akowuah GA. Content of luteolin and luteolin-7-О-glucoside from the leaves of Vernonia amygdalina Del., and synergistic inhibitory effect with cisplatin on nasopharyngeal carcinoma cells. Chemical Data Collections. 2023;45:101039  https://doi.org/10.1016/j.cdc.2023.101039
  15. Wu Q, Ma X, Jin Z, Ni R, Pan Y, Yang G. Zhuidu Formula suppresses the migratory and invasive properties of triple-negative breast cancer cells via dual signaling pathways of RhoA/ROCK and CDC42/MRCK. Journal of Ethnopharmacology. 2023;116644.  https://doi.org/10.1016/j.jep.2023.116644
  16. Donkor MN, Donkor AM, Mosobil R. Combination therapy: synergism among three plant extracts against selected pathogens. BMC Research Notes. 2023;16(1):83.  https://doi.org/10.1186/s13104-023-06354-7
  17. Wang C, Zhang J, Wei X, Yang M, Ma W, Yu R, Liu M, Jiang T. Design, Synthesis, and Biological Evaluation of Marine Lissodendrins B Analogues as Modulators of ABCB1-Mediated Multidrug Resistance. Marine Drugs. 2023; 21(5):314.  https://doi.org/10.3390/md21050314

V. Environmental and Toxins

  1. Bei ZC, Li GF, Zhao JH, Zhang M, Ji XG, Wang JY. Evaluation of the combination of azithromycin and naphthoquine in animal malaria models. Antimicrob Agents Chemother. 2020;64(11).  https://doi.org/10.1128/aac.02307-19
  2. Pereira, LM, Mota, CM, Baroni, L, da Costa CMB, Brochi JCV, Wainwright M, Mineo TWP, Braga GUL, Yatsuda AP. Inhibitory action of phenothiazinium dyes against Neospora caninum. Scientific Reports. 2020;10(7483).  https://doi.org/10.1038/s41598-020-64454-x
  3. Luo H, Li J, Song B, Zhang B, Li Y, Zhou Z, Chang X. The binary combined toxicity of lithium, lead, and manganese on the proliferation of murine neural stem cells using two different models. Environ Sci Pollut Res. August 2022.  https://doi.org/10.1007/s11356-022-22433-x
  4. Huang P, Wang Y, Liu SS, Wang ZJ, Xu YQ. SAHmap: Synergistic-antagonistic heatmap to evaluate the combined synergistic effect of mixtures of three pesticides on multiple endpoints of Caenorhabditis elegans. Environmental Pollution. 2022;315(15).  https://doi.org/10.1016/j.envpol.2022.120378
  5. Wu Y, Ding H, Wan L, Zhang W, Zhang Y, Yang L, Zhao C. Single and combined toxic effects of clarithromycin and levofloxacin on Microcystis aeruginosa. Environmental Pollutants and Bioavailability. 2022;34(1):482-495.  https://doi.org/10.1080/26395940.2022.2130825
  6. Rodea-Palomares I, Gao Z, Weyers A, Ebeling M. Risk from unintentional environmental mixtures in EU surface waters is dominated by a limited number of substances. Science of The Total Environment. 2023;856(2).  https://doi.org/10.1016/j.scitotenv.2022.159090
  7. Zhang L, Zheng X, Liu X, Li J, Li Y, Wang Z, Zheng N, Wang X, Fan Z. Toxic effects of three perfluorinated or polyfluorinated compounds (PFCs) on two strains of freshwater algae: Implications for ecological risk assessments. Journal of Environmental Sciences. 2023;131:48-58.  https://doi.org/10.1016/j.jes.2022.10.042
  8. Fuel M, Mesas C, Martínez R, Ortiz R, Quiñonero F, Bermúdez F, Gutiérrez N, Torres AM, Kapravelou G, Lozano A, Perazzoli G, Prados J, Porres JM, Melguizo C. Antioxidant and chemopreventive activity of protein hydrolysates from raw and germinated flour of legumes with commercial interest in colorectal cancer. Antioxidants. 2022;11(12):2421.  https://doi.org/10.3390/antiox11122421
  9. Chen J. Timed hazard networks: Incorporating temporal difference for oncogenetic analysis. PLoS One. 2023;18(3):e0283004.  https://doi.org/10.1371/journal.pone.0283004
  10. Zhang L, Zheng X, Liu X, Li J, Li Y, Wang Z, Zheng N, Wang X, Fan Z. Toxic effects of three perfluorinated or polyfluorinated compounds (PFCs) on two strains of freshwater algae: Implications for ecological risk assessments. Journal of Environmental Sciences. 2023;131:48-58.  https://doi.org/10.1016/j.jes.2022.10.042

VI. Radiation, Photo-dynamics, Thermo-dynamics, UV and Microwave

  1. Chen J, Li DL, Xie LN, Ma YR, Wu PP, Li C, Liu WF, Zhang K, Zhou RP, Xu XT, Zheng X, Liu X. Synergistic anti-inflammatory effects of silibinin and thymol combination on LPS-induced RAW264.7 cells by inhibition of NF-κB and MAPK activation. Phytomedicine. 2020;78:153309.  https://doi.org/10.1016/j.phymed.2020.153309
  2. Dukel M, Fiskin K. Combination of PAKs inhibitors IPA-3 and PF-3758309 effectively suppresses colon carcinoma cell growth by perturbing DNA damage response. International Journal of Radiation Biology. August 2022. (In press)  https://doi.org/10.1080/09553002.2022.2110326
  3. Yanga P, Chang Y, Zhanga J, Gao F, Liu X, Wei Q, Ma X, Guo Y. The combination of in situ photodynamic promotion and ion-interference to improve the efficacy of cancer therapy. Journal of Colloid and Interface Science. 22 August 2022.  https://doi.org/10.1016/j.jcis.2022.08.125
  4. Lima GAS, Guerini GG, de Vasconcellos SP, Pellosi DS. Visible light-induced synergic antimicrobial activity of silver nanoparticles/methylene blue nanohybrids encapsulated in chitosan and pluronic polymers. Chemical Papers. 27 September 2022.  https://doi.org/10.1007/s11696-022-02509-1
  5. Liu Y, Betori RC, Pagacz J, Frost GB, Efimova EV, Wu D, Wolfgeher DJ, Bryan TM, Cohen SB, Scheidt KA, Kron SJ. Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization. Cell Chemical Biology. 2022;29(10): 1517-1531.  https://doi.org/10.1016/j.chembiol.2022.09.002
  6. Mao W, Chen J, Wang Y, Fang Y, Wu H, He P. Combination of carboplatin and photodynamic therapy with 9-hydroxypheophorbide ɑ enhances mitochondrial and endoplasmic reticulum apoptotic effect in AMC-HN-3 laryngeal cancer cells. Photodiagnosis and Photodynamic Therapy. 2022;103135.  https://doi.org/10.1016/j.pdpdt.2022.103135
  7. Li Y, Dang G, Rizwan Younis M, Cao Y, Wang K, Sun X, Zhang W, Zou X, Shen H, An R, Dong L, Dong J. Peptide functionalized actively targeted MoS2 nanospheres for fluorescence imaging-guided controllable pH-responsive drug delivery and collaborative chemo/photodynamic therapy. Journal of Colloid and Interface Science. 2023; 639:302-313  https://doi.org/10.1016/j.jcis.2023.02.027
  8. Atchan APN, Monthe OC, Tchamgoue AD, Singh Y, Shivashankara ST, Selvi MK, Agbor GA, Magni P, Piazza S, Manjappara UV, Kuiate J-R, Dell’Agli M. Anti-inflammatory, antioxidant activities, and phytochemical characterization of edible plants exerting synergistic effects in human gastric epithelial cells. Antioxidants. 2023;12(3):591.  https://doi.org/10.3390/antiox12030591
  9. Gao J, Luan T, Lv J, Yang M, Li H, Yuan Z. An oxygen-carrying and lysosome-targeting BODIPY derivative for NIR bioimaging and enhanced multimodal therapy against hypoxic tumors. Journal of Photochemistry and Photobiology B: Biology. 2023;241.  https://doi.org/10.1016/j.jphotobiol.2023.112666
  10. Chen J. Timed hazard networks: Incorporating temporal difference for oncogenetic analysis. PLoS One. 2023;18(3):e0283004.  https://doi.org/10.1371/journal.pone.0283004
  11. Shrivastava N, Chavez CG, Li D, Mehta V, Thomas C, Fulcher CD, Kawachi N, Bottalico DM, Prystowsky MB, Basu I, Guha C, Ow TJ. CDK4/6 inhibition induces senescence and enhances radiation response by disabling DNA damage repair in oral cavity squamous cell carcinoma. Cancers. 2023;15(7):2005.  https://doi.org/10.3390/cancers15072005
  12. Chou TC. Mass-action law dynamic theory-based “top-down” approach with observation/statistics-based “bottom-up” approach for bioinformatics in biomedical R&D. ASPET 2023 Annual Meeting. St. Louis, MO, May 18-21, 2023.  https://doi.org/10.1124/jpet.122.185320
  13. Ning C, Dong Y, Yang K, Li X, Wang F, Zhang Y. Co-Encapsulation of hydrophilic and hydrophobic drugs into human H chain ferritin nanocarrier enhances antitumor efficacy. ACS Biomaterials Science & Engineering. 2023;10.1021/acsbiomaterials.3c00218.  https://doi.org/10.1021/acsbiomaterials.3c00218
  14. Malarz K, Mularski J, Pacholczyk M, Musiol R. Styrylquinazoline derivatives as ABL inhibitors selective for different DFG orientations. Journal of Enzyme Inhibition and Medicinal Chemistry. 2023;38(1):2201410.  https://doi.org/10.1080/14756366.2023.2201410
  15. Coverdale JPC, Kostrhunova H, Markova L, Song H, Postings M, Bridgewater HE, Brabec V, Rogers NJ, Scott P. Triplex metallohelices have enantiomer-dependent mechanisms of action in colon cancer cells. Dalton Transactions. 2023;10.1039/d3dt00948c.  https://doi.org/10.1039/d3dt00948c
  16. Liu M, Luo Y, Yan J, Xiong X, Xing X, Kim JS, Zou T. Photoactivation of boronic acid prodrugs via a phenyl radical mechanism: Iridium(III) anticancer complex as an example. Journal of the American Chemical Society. April 26, 2023.  https://doi.org/10.1021/jacs.3c00254

VII. Nanoparticles, Material Science

  1. Qiao Y, Xu Y, Liu X, et al. Microwave assisted antibacterial action of Garcinia nanoparticles on Gram-negative bacteria. Nat Commun. 2022;13:2461.  https://doi.org/10.1038/s41467-022-30125-w
  2. Xie Q, Li B, Fan J, Liang J, Jiang S, Qin Y, Jiang L, Cui J, Nie X, Sun S, Liu B, Wang W. Biomimetic hybrid-cell membrane nanoparticles loaded with panaxytriol for breast cancer combinational therapy. Materials & Design. 2022;223.  https://doi.org/10.1016/j.matdes.2022.111219
  3. Behl A, Solanki S., Paswan, SK, Datta TK, Saini AK, Saini RV, Parmar VS, Thakur VK, S Malhotra, Chhillar AK. Biodegradable PEG-PCL nanoparticles for co-delivery of MUC1 inhibitor and doxorubicin for the confinement of triple-negative breast cancer. Journal of Polymers and the Environment. November 11, 2022.  https://doi.org/10.1007/s10924-022-02654-4
  4. Wang L, Evans JC, Ahmed L, Allen C. Folate receptor targeted nanoparticles containing niraparib and doxorubicin as a potential candidate for the treatment of high grade serous ovarian cancer. Scientific Reports. 2023;13(1):3226.  https://doi.org/10.1038/s41598-023-28424-3
  5. Zheng Y, Liu Y, Wu Z, Peng C, Wang Z, Yan J, Yan Y, Li Z, Liu C, Xue J, Tan H, Fu Q, Ding M. Photoallosteric polymersomes toward on-demand drug delivery and multimodal cancer immunotherapy. Advanced Materials. February 28, 2023.  https://doi.org/10.1002/adma.202210986
  6. Synowiec A, Brodaczewska K, Wcisło G, Majewska A, Borkowska A, Filipiak-Duliban A, Gawrylak A, Wilkus K, Piwocka K, Kominek A, Waś H, Lewicki S, Siewiera J, Szczylik C, Szenajch J, Kubiak JZ, Kieda C. Hypoxia, but Not normoxia, reduces effects of resveratrol on cisplatin treatment in A2780 ovarian cancer cells: A challenge for resveratrol use in anticancer adjuvant cisplatin therapy. International Journal of Molecular Sciences. 2023;24(6):5715.  https://doi.org/10.3390/ijms24065715
  7. Graván P, Aguilera-Garrido A, Marchal JA, Navarro-Marchal SA, Galisteo-Gonzalez F. Lipid-core nanoparticles: Classification, preparation methods, routes of administration and recent advances in cancer treatment. Advances in Colloid and Interface Science. 2023;314:102871.  https://doi.org/10.1016/j.cis.2023.102871
  8. Paul S, Mukherjee S, Banerjee P. Recent advancement in the Nanomaterials encapsulated drug delivery vehicles towards combating of Cancer, COVID-19 and HIV like chronic diseases. Materials Advances. March 30, 2023.  https://doi.org/10.1039/D2MA01075E
  9. Zheng Y, Liu Y, Wu Z, Peng C, Wang Z, Yan J, Yan Y, Li Z, Liu C, Xue J, Tan H, Fu Q, Ding M. Photoallosteric polymersomes toward on-demand drug delivery and multimodal cancer immunotherapy. Advanced Materials. 2023;e2210986.  https://doi.org/10.1002/adma.202210986
  10. Shin YB, Choi JY, Shin DH, Lee JW. Anticancer evaluation of methoxy poly(ethylene glycol)-b-poly(caprolactone) polymeric micelles encapsulating fenbendazole and rapamycin in ovarian cancer. International Journal of Nanomedicine. 2023;18:2209-2223.  https://doi.org/10.2147/IJN.S394712
  11. Yeo S, Kim MJ, Yoon I, Lee WK. pH-responsive nano-transferosomes of purpurin-18 sodium salt and doxorubicin for enhanced anticancer efficiency by photodynamic and chemo combination therapy. ACS Omega. April 26, 2023.  https://doi.org/10.1021/acsomega.3c01654
  12. Shin YB, Choi JY, Shin DH, Lee JW. Anticancer evaluation of methoxy poly(ethylene glycol)-b-poly(caprolactone) polymeric micelles encapsulating fenbendazole and rapamycin in ovarian cancer. International Journal of Nanomedicine. 2023;18:2209-2223.  https://doi.org/10.2147/IJN.S394712
  13. Chu W, Houston ZH, Fletcher NL, Huda P, Ahamed M, Lim TX, Day BW, Pinkham M, Thurecht KJ. Development and Validation of a Targeted Treatment for Brain Tumors Using a Multi-Drug Loaded, Relapse-Resistant Polymeric Theranostic. Biomacromolecules. 2023;10.1021/acs.biomac.3c00138.  https://doi.org/10.1021/acs.biomac.3c00138
  14. Silvestrini AVP, Garcia Praça F, Leite MN, de Abreu Fantini MC, Frade MAC, Badra Bentley MVL. Liquid crystalline nanoparticles enable a multifunctional approach for topical psoriasis therapy by co-delivering triptolide and siRNAs. International Journal of Pharmaceutics. 2023;640:123019.  https://doi.org/10.1016/j.ijpharm.2023.123019
  15. Kwon EJ, Mashelkar KK, Seo J, Shin YZ, Sung K, Jang SC, Cheon SW, Lee H, Lee HW, Kim G, Han BW, Lee SK, Jeong LS, Cha HJ. In silico 5’-modified 7-deoxy-7-ethynyl-4’-adenosine as a HASPIN inhibitor and its synergistic anticancer effect with the PLK1 inhibitor. ACS Central Science. May 11, 2023.  https://doi.org/10.1021/acscentsci.3c00332
  16. Yu Y, Shen X, Xiao X, Li L, Huang Y. Butyrate modification promotes intestinal absorption and hepatic cancer cells targeting of ferroptosis inducer loaded nanoparticle for enhanced hepatocellular carcinoma therapy. Small. 2023;e2301149.  https://doi.org/10.1002/smll.202301149
  17. Mason DJ. Novel materials comprised of molecular springs: synthetic approaches to bridgehead-substituted bicyclo[n.n.n]alkane monomers. Ph.D thesis, The University of Arizona. 2023.
  18. Harris CR, Balog A, Savin K, Danishefsky SJ, Chou TC, Zhang XG. ChemInform Abstract: Epothilones: Microtubule stabilizing agents with enhanced activity against multidrug-resistant cell lines and tumors. ChemInform. 2001;32(12).  https://doi.org/10.1002/chin.200112285
  19. Yusoh NA, Tiley PR, James SD, Harun SN, Thomas JA, Saad N, Hii LW, Chia SL, Gill MR, Ahmad H. Discovery of ruthenium(II) metallocompound and olaparib synergy for cancer combination therapy. Journal of Medicinal Chemistry. 2023;10.1021/acs.jmedchem.3c00322.  https://doi.org/10.1021/acs.jmedchem.3c00322
  20. Zheng Y, Zheng J, Du M, Yang Y, Li X, Chen H, Gao Y. An iron-containing ferritin-based nanosensitizer for synergistic ferroptosis/sono-photodynamic cancer therapy. Journal of Materials Chemistry. 2023;10.1039/d3tb00029j.  https://doi.org/10.1039/d3tb00029j

VIII.    AI, Machine Learning, and Ensemble

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  2. Gautam UK, Rashid TA, Nizamani QUA, Mubasher R, Costadopoulos N, Salah RM, Alrubaie A. Deep learning algorithm for predicting drug synergy against cancer: data, drug feature extraction, prediction and view (DDPV) taxonomy. Proceedings of the ICR’22 International Conference on Innovations in Computing Research. Advances in Intelligent Systems and Computing. 2022;1431:261–269.  https://doi.org/10.1007/978-3-031-14054-9_25
  3. Thafar MA. Drug repositioning through the development of diverse computational methods using machine learning, deep learning, and graph mining. PhD dissertation, King Abdullah University of Science and Technology. 2022.  http://hdl.handle.net/10754/679796  doi:  10.25781/KAUST-02A06
  4. Preto AJ, Matos-Filipe P, Mourão J, Moreira IS. SYNPRED: prediction of drug combination effects in cancer using different synergy metrics and ensemble learning. GigaScience. 2022;11.  https://doi.org/10.1093/gigascience/giac087
  5. Ye Q, Hsieh CY, Yang Z, Kang Y, Chen J, Cao D, He S, Hou T. A unified drug-target interaction prediction framework based on knowledge graph and recommendation system. Nature Communications. 2021;12(1):6775.  https://doi.org/10.1038/s41467-021-27137-3
  6. Li J, Chen X, Huang Q, Wang Y, Xie Y, Dai Zong, Zou X, Li Z. Seq-SymRF: a random forest model predicts potential miRNA-disease associations based on information of sequences and clinical symptoms. Scientific Reports. 2020;10(17901).  https://doi.org/10.1038/s41598-020-75005-9
  7. Roth BJ. A mathematical model of mechanotransduction. Academia Biology. 2023;1.  https://doi.org/10.20935/AcadBiol6081
  8. Janizek JD, Dincer AB, Celik S, Chen H, Chen W, Naxerova K, Lee SI. Uncovering expression signatures of synergistic drug responses via ensembles of explainable machine-learning models. Nature Biomedical Engineering. 2023;10.1038/s41551-023-01034-0.  https://doi.org/10.1038/s41551-023-01034-0

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